MDMA + SSRI = wasted drugs.

I'd like to share two anecdotal reports of using mdma while currently taking an ssri medication. There are two stories to tell:

The first is about a girl, we'll name her Nelly. She has been taking the ssri medication escitalopram 20 mg per day to treat anxiety and sleep issues for about two months now. On a Thursday night a while back, she and her boyfriend decided to take some molly (crystalline mdma). A friend's test kit revealed it to be at least 90 percent pure product, and they had a cool place to roll , just the two of them that night. Each of them decided to eat a point (100 mg) of the substance around 7:30 pm. Within 40 minutes or so, her boyfriend's muscles became mush as he sank into the sofa. Thirty minutes later he was rubbing up against the wall, slowly dropping down to the floor, feeling everything: literally, he was rolling. But Nelly, she felt nothing. So she took another half of a point, this time sniffing it versus orally as she had done earlier. Two hours after initial ingestion, she did a whole nother point. It was at that moment that her boyfriend, rolling fucking FACE and empathetically as possible sighed and told her "damn.... I know why you don't feel it. Cause of the ssri youre taking!" While her boyfriend got a solid 4 hour orgasm essentially, she got nothing from a quarter of a gram of the substance!

Meanwhile, Ellie, a 17-year old girl taking citalopram for the past 3-4 years for depression, tried molly for the first time some time back, reporting that she "kind of felt it" but was nothing amazing. clearly if youve ever done mdma, you'd know that it isn't just a cheap little buzz--it's supposed to blow your mind via its euphoria. I mean come on, it's ecstasy!

Since both mdma and ssris (selective serotonin reuptake inhibitors) both work thru serotonin, the ssri cancelled out the molly. It's possible that since Elly had been taking it for a longer period of time that she was able to bypass a bit of its inhibitory effects. Nonetheless, if you want a good roll, one cannot be on ssris. The "best" case scenario would involve not feeling it or only catching a tinge of a buzz. Worst case scenario: serotonin syndrome, a potentially life-threatening condition in which your brain is flooded with the chemical. All across the internet, various users recommend varying time frames of abstinence from their ssri medication to be able to feel the mdma. 3 days. 1 week. 1 month. It's probably unwise to stop taking those meds to roll though, especially if prescribed for depression, seeing as the mdma comedown can incite horrific apathy and sadness.